Risk factors for graves' orbitopathy; The australian thyroid-associated orbitopathy research (ATOR) study

Abstract

Context: Previous association studies suggest the development of Graves' orbitopathy (GO) is variably influenced by environmental risk factors. Objective: To determine the risk factors and predict odds for developing GO in Graves' hyperthyroidism (GH). Design: Case-control study. Setting: Multi-centre Australian Thyroid-associated Orbitopathy Research group consisting of tertiary endocrinology and ophthalmology outpatients and related private practices. Patients or Other Participants: A total of 1042 participants with GH were designated as cases if they had GO (n = 604) and controls if they did not have GO (n = 438). Main Outcome Measures: Primary outcome was GO risk factors and secondary ou..