Journal article
Epigenetic markers to predict conversion from gestational diabetes to type 2 diabetes
AA Michalczyk, JA Dunbar, ED Janus, JD Best, PR Ebeling, MJ Ackland, D Asproloupos, ML Ackland
Journal of Clinical Endocrinology and Metabolism | Published : 2016
DOI: 10.1210/jc.2015-4206
Abstract
Context: Lifestyle factors mediate epigenetic changes that can cause chronic diseases. Although animal and laboratory studies link epigenetic changes to diabetes, epigenetic information in women with gestational diabetes (GDM) and type 2 diabetes is lacking. Objective: This study sought to measure epigenetic markers across pregnancy and early postpartum and identify markers that could be used as predictors for conversion from GDM to type 2 diabetes. Design: Global histone H3 dimethylation was measured in white blood cells at three time points: 30 wk gestation, 8-10 wk postpartum, and 20 wk postpartum, from four groups of women with and without diabetes. Setting and Participants: A total of 3..
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Funding Acknowledgements
This work was supported by funding from the Greater Green Triangle University Department of Rural Health, Deakin and Flinders Universities; The University of Melbourne; and Deakin University.