Journal article

Antibody Responses with Fc-Mediated Functions after Vaccination of HIV-Infected Subjects with Trivalent Influenza Vaccine

Anne B Kristensen, William N Lay, Fernanda Ana-Sosa-Batiz, Hillary A Vanderven, Vijaya Madhavi, Karen L Laurie, Louise Carolan, Bruce D Wines, Mark Hogarth, Adam K Wheatley, Stephen J Kent

JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2016

Abstract

UNLABELLED: This study seeks to assess the ability of seasonal trivalent inactivated influenza vaccine (TIV) to induce nonneutralizing antibodies (Abs) with Fc-mediated functions in HIV-uninfected and HIV-infected subjects. Functional influenza-specific Ab responses were studied in 30 HIV-negative and 27 HIV-positive subjects immunized against seasonal influenza. All 57 subjects received the 2015 TIV. Fc-mediated antihemagglutinin (anti-HA) Ab activity was measured in plasma before and 4 weeks after vaccination using Fc-receptor-binding assays, NK cell activation assays, and phagocytosis assays. At baseline, the HIV-positive group had detectable but reduced functional Ab responses to both va..

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