Antibody Responses with Fc-Mediated Functions after Vaccination of HIV-Infected Subjects with Trivalent Influenza Vaccine
Anne B Kristensen, William N Lay, Fernanda Ana-Sosa-Batiz, Hillary A Vanderven, Vijaya Madhavi, Karen L Laurie, Louise Carolan, Bruce D Wines, Mark Hogarth, Adam K Wheatley, Stephen J Kent
JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2016
UNLABELLED: This study seeks to assess the ability of seasonal trivalent inactivated influenza vaccine (TIV) to induce nonneutralizing antibodies (Abs) with Fc-mediated functions in HIV-uninfected and HIV-infected subjects. Functional influenza-specific Ab responses were studied in 30 HIV-negative and 27 HIV-positive subjects immunized against seasonal influenza. All 57 subjects received the 2015 TIV. Fc-mediated antihemagglutinin (anti-HA) Ab activity was measured in plasma before and 4 weeks after vaccination using Fc-receptor-binding assays, NK cell activation assays, and phagocytosis assays. At baseline, the HIV-positive group had detectable but reduced functional Ab responses to both va..View full abstract
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Awarded by Australia-India Strategic Research Fund (AISRF)
Awarded by National Health and Medical Research Council (NHMRC) (Australia)
This work, including the efforts of Stephen J. Kent, was funded by Australia-India Strategic Research Fund (AISRF) (AISRF08020). This work, including the efforts of Stephen J. Kent, was funded by National Health and Medical Research Council (NHMRC) (Australia) (1041832, 1042634, and 1052979).