Journal article

Variation in relapse frequency and the transmission potential of Plasmodium vivax malaria

Michael T White, George Shirreff, Stephan Karl, Azra C Ghani, Ivo Mueller

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | ROYAL SOC | Published : 2016

Abstract

There is substantial variation in the relapse frequency of Plasmodium vivax malaria, with fast-relapsing strains in tropical areas, and slow-relapsing strains in temperate areas with seasonal transmission. We hypothesize that much of the phenotypic diversity in P. vivax relapses arises from selection of relapse frequency to optimize transmission potential in a given environment, in a process similar to the virulence trade-off hypothesis. We develop mathematical models of P. vivax transmission and calculate the basic reproduction number R0 to investigate how transmission potential varies with relapse frequency and seasonality. In tropical zones with year-round transmission, transmission poten..

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Grants

Awarded by Population Health Scientist fellowship from the MRC


Awarded by NHMRC Senior Research Fellowship


Awarded by NHMRC Early Career Fellowship


Awarded by Medical Research Council


Funding Acknowledgements

M.T.W. is funded by a Population Health Scientist fellowship from the MRC (MR/L012170/1). A.C.G. acknowledges support from the Bill and Melinda Gates Foundation and MRC Centre funding. I.M. is supported by an NHMRC Senior Research Fellowship (#1043345). S.K. was supported by an NHMRC Early Career Fellowship (#1052760). I.M. and S.K. acknowledge support from the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS.