Journal article

Pericytes Promote Malignant Ovarian Cancer Progression in Mice and Predict Poor Prognosis in Serous Ovarian Cancer Patients

Devbarna Sinha, Lynn Chong, Joshy George, Holger Schlueter, Susann Moenchgesang, Stuart Mills, Jason Li, Christopher Parish, David Bowtell, Pritinder Kaur



PURPOSE: The aim of this study was to investigate the role of pericytes in regulating malignant ovarian cancer progression. EXPERIMENTAL DESIGN: The pericyte mRNA signature was used to interrogate ovarian cancer patient datasets to determine its prognostic value for recurrence and mortality. Xenograft models of ovarian cancer were used to determine if co-injection with pericytes affected tumor growth rate and metastasis, whereas co-culture models were utilized to investigate the direct effect of pericytes on ovarian cancer cells. Pericyte markers were used to stain patient tissue samples to ascertain their use in prognosis. RESULTS: Interrogation of two serous ovarian cancer patient datasets..

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Awarded by Cancer Council of Victoria

Awarded by NHMRC

Awarded by US Army Medical Research and Materiel Command Grant

Awarded by Cancer Australia

Funding Acknowledgements

This work was supported by the CASS Foundation, Cancer Council of Victoria # 807184 and NHMRC # 1025874 grants to P. Kaur and US Army Medical Research and Materiel Command Grant DAMD17 01 1 0729, the Cancer Council Tasmania, the 618 Cancer Foundation of Western Australia, NHMRC # 400413 and Cancer Australia # 1004673 to D. Bowtell. D. Sinha was supported by an International HDR PhD scholarship from ANU, Canberra.