Journal article

Using the rd1 mouse to understand functional and anatomical retinal remodelling and treatment implications in retinitis pigmentosa: A review

M Kalloniatis, L Nivison-Smith, J Chua, ML Acosta, EL Fletcher

EXPERIMENTAL EYE RESEARCH | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2016

Abstract

Retinitis Pigmentosa (RP) reflects a range of inherited retinal disorders which involve photoreceptor degeneration and retinal pigmented epithelium dysfunction. Despite the multitude of genetic mutations being associated with the RP phenotype, the clinical and functional manifestations of the disease remain the same: nyctalopia, visual field constriction (tunnel vision), photopsias and pigment proliferation. In this review, we describe the typical clinical phenotype of human RP and review the anatomical and functional remodelling which occurs in RP determined from studies in the rd/rd (rd1) mouse. We also review studies that report a slowing down or show an acceleration of retinal degenerati..

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University of Melbourne Researchers

Grants

Awarded by University of New South Wales


Awarded by National Health and Medical Research Council (NHMRC)


Awarded by Health Research Council of New Zealand


Awarded by NHMRC


Funding Acknowledgements

This work was supported, in part, by grants from the University of New South Wales (Early Career Research Grant 2015 (#P535430)), National Health and Medical Research Council (NHMRC) grants (#1033224, #1009342, #1021042), Health Research Council of New Zealand (05/247), and Retina Australia. Guide Dogs NSW/ACT is a partner in the NHMRC grant #1033224.