Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist

Nitin A Patil; Richard A Hughes; K Johan Rosengren; Martina Kocan; Sheng Yu Ang; Julien Tailhades; Frances Separovic; Roger J Summers; Johannes Grosse; John D Wade; Ross AD Bathgate; Mohammed Akhter Hossain

Journal article

Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist

Nitin A Patil, Richard A Hughes, K Johan Rosengren, Martina Kocan, Sheng Yu Ang, Julien Tailhades, Frances Separovic, Roger J Summers, Johannes Grosse, John D Wade, Ross AD Bathgate, Mohammed Akhter Hossain

Journal of Medicinal Chemistry | AMER CHEMICAL SOC | Published : 2016

DOI: 10.1021/acs.jmedchem.5b01786

University of Melbourne Researchers

Frances Separovic Author Chemistry

Akhter Hossain Author Florey Department of Neuroscience and Mental Health

Ross Bathgate Author Florey Department of Neuroscience and Mental Health

John Wade Author Florey Department of Neuroscience and Mental Health

Martina Kocan Author Florey Department of Neuroscience and Mental Health

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Grants

Awarded by NHMRC (Australia)

Awarded by ARC

Awarded by NHMRC

Funding Acknowledgements

This research was partly funded by NHMRC (Australia) project grants (1023321, 1065481, and 1023078) to M.A.H., R.A.D.B., J.K.R., and J.D.W., and ARC linkage grant (LP120100654) to R.A.H. K.J.R. is an Australian Research Council Future Fellow (FT130100890). R.J.S. and M.K. funded by NHMRC Program Grant 1055134 to R.J.S. and S.Y.A. by a Monash Graduate Scholarship and Monash International Postgraduate Research Scholarship. We are grateful to Tania Ferraro and Sharon Layfield for assistance with biochemical assays and to Feng Lin for amino acid analysis. During these studies, MAH was the recipient of Florey Foundation Fellowships. R.A.D.B. is an NHMRC Senior Research Fellow, and J.D.W. is an NHMRC Principal Research Fellow. Studies at the FNI were supported by the Victorian Government's Operational Infrastructure Support Program.