Journal article
A molecular classification of human mesenchymal stromal cells
Florian Rohart, Elizabeth A Mason, Nicholas Matigian, Rowland Mosbergen, Othmar Korn, Tyrone Chen, Suzanne Butcher, Jatin Patel, Kerry Atkinson, Kiarash Khosrotehrani, Nicholas M Fisk, Kim-Anh Le Cao, Christine A Wells
PEERJ | PEERJ INC | Published : 2016
DOI: 10.7717/peerj.1845
Abstract
Mesenchymal stromal cells (MSC) are widely used for the study of mesenchymal tissue repair, and increasingly adopted for cell therapy, despite the lack of consensus on the identity of these cells. In part this is due to the lack of specificity of MSC markers. Distinguishing MSC from other stromal cells such as fibroblasts is particularly difficult using standard analysis of surface proteins, and there is an urgent need for improved classification approaches. Transcriptome profiling is commonly used to describe and compare different cell types; however, efforts to identify specific markers of rare cellular subsets may be confounded by the small sample sizes of most studies. Consequently, it i..
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Awarded by Australian Research Council
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Awarded by NHMRC
Funding Acknowledgements
This work was funded by an Australian Research Council Grant SR1101002 to Stem Cells Australia (CAW), ARC discovery project DP130100777 to CAW and KALC, JEM Research Foundation philanthropic funding to CAW, and an NHMRC project grant APP1023368 to NMF and KK. CAW is funded by a QLD Government Smart Futures Fellowship. KK was supported by NHMRC career development fellowship 1023371. JP was supported by the National Heart Foundation Australia. KALC is funded in part by the Australian Cancer Research Foundation (ACRF) for the Diamantina Individualised Oncology Care Centre at the University of Queensland Diamantina Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.