Journal article
Clinical management of catecholaminergic polymorphic ventricular tachycardia the role of left cardiac sympathetic denervation
GM De Ferrari, V Dusi, C Spazzolini, JM Bos, DJ Abrams, CI Berul, L Crotti, AM Davis, M Eldar, M Kharlap, A Khoury, AD Krahn, A Leenhardt, CR Moir, A Odero, LO Nordkamp, T Paul, F Rosés I Noguer, M Shkolnikova, J Till Show all
Circulation | Published : 2015
Abstract
Background-Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic disorder causing life-threatening arrhythmias whenever sympathetic activity increases. β-Blockers are the mainstay of therapy; when they fail, implantable cardioverter-defibrillators (ICDs) are used but often cause multiple shocks. Preliminary results with flecainide appear encouraging. We proposed left cardiac sympathetic denervation (LCSD) as useful additional therapy, but evidence remains anecdotal. Methods and Results-We report 63 patients with CPVT who underwent LCSD as secondary (n=54) or primary (n=9) prevention. The median post-LCSD follow-up was 37 months. The 9 asymptomatic patients remained free o..
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