Selenium and vitamin E together improve intestinal epithelial barrier function and alleviate oxidative stress in heat-stressed pigs
Fan Liu, Jeremy J Cottrell, John B Furness, Leni R Rivera, Fletcher W Kelly, Udani Wijesiriwardana, Ruslan V Pustovit, Linda J Fothergill, David M Bravo, Pietro Celi, Brian J Leury, Nicholas K Gabler, Frank R Dunshea
EXPERIMENTAL PHYSIOLOGY | WILEY | Published : 2016
What is the central question of this study? Oxidative stress may play a role in compromising intestinal epithelial barrier integrity in pigs subjected to heat stress, but it is unknown whether an increase of dietary antioxidants (selenium and vitamin E) could alleviate gut leakiness in heat-stressed pigs. What is the main finding and its importance? Levels of dietary selenium (1.0 p.p.m.) and vitamin E (200 IU kg(-1) ) greater than those usually recommended for pigs reduced intestinal leakiness caused by heat stress. This finding suggests that oxidative stress plays a role in compromising intestinal epithelial barrier integrity in heat-stressed pigs and also provides a nutritional strategy f..View full abstract
Awarded by Commonwealth Department of Agriculture and Water Resources Carbon Farming Futures Program
Research was primarily funded by the Commonwealth Department of Agriculture and Water Resources Carbon Farming Futures Program (194374-167). Work in Professor Furness's laboratory was supported by InVivo Animal Nutrition & Health, through its subsidiary, Pancosma SA. F.L. received an Australian Postgraduate Award, an International Postgraduate Research Scholarship, and a study award from Australian Pork Limited. L.R.R. was supported by National Health and Medical Research Council (NHMRC) Peter Doherty Fellowship.