Journal article
Perinatal microbial exposure may influence aortic intima-media thickness in early infancy
K McCloskey, P Vuillermin, JB Carlin, M Cheung, MR Skilton, MLK Tang, K Allen, GL Gilbert, S Ranganathan, F Collier, T Dwyer, AL Ponsonby, D Burgner
International Journal of Epidemiology | Published : 2017
DOI: 10.1093/ije/dyw042
Abstract
Background: The maternal and infant microbiome may influence infant cardiovascular risk through immune programming. The maternal vagino-enteric microbiome is often sampled for group B streptococcus (GBS) colonization during pregnancy. Our aim was to investigate the association between maternal GBS colonization, intrapartum antibiotics, antenatal pet exposure and infant aortic intima-media thickness (aIMT), an intermediate vascular phenotype, and whether this association varied by mode of delivery. Methods: The Barwon Infant Study is a population-derived pre-birth cohort. Perinatal data were collected on participants. Women were tested for vagino-enteric group B streptococcus (GBS) colonizati..
View full abstractGrants
Awarded by Jack Brockhoff Foundation
Funding Acknowledgements
The initial establishment work and infrastructure for the BIS was supported by the Murdoch Childrens Research Institute and Barwon Health. Deakin University is now a partner organization and has provided funding and infrastructure. Funding has been provided by the National Health and Medical Research Council of Australia (APP607370, APP1009044, APP102997, APP1082037, APP1076667, APP1030701 and APP1084017), the Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, Our Women's Our Children's Fundraising Committee Barwon Health, the Rotary Club of Geelong, the Shepherd Foundation and the Ilhan Foundation. K.M. is funded by a Sidney Myer Scholarship. D.B. is supported by a National Health and Medical Research Council (Australia) Fellowship [APP1064629] and an Honorary Future Leader Fellowship of the National Heart Foundation of Australia (100369). M.S. is supported by a Future Leader Fellowship from the National Heart Foundation of Australia (#100419). Research at Murdoch Childrens Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. The Heart Research Group at Murdoch Childrens Research Institute is supported by Big W, RCH 1000 and the RCH Foundation.