Journal article
Genetic Associations With White Matter Hyperintensities Confer Risk of Lacunar Stroke
M Traylor, LCA Rutten-Jacobs, V Thijs, EG Holliday, C Levi, S Bevan, R Malik, G Boncoraglio, C Sudlow, PM Rothwell, M Dichgans, HS Markus
Stroke | Published : 2016
Open access
Abstract
Background and Purpose - White matter hyperintensities (WMH) are increased in patients with lacunar stroke. Whether this is because of shared pathogenesis remains unknown. Using genetic data, we evaluated whether WMH-associated genetic susceptibility factors confer risk of lacunar stroke, and therefore whether they share pathogenesis. Methods - We used a genetic risk score approach to test whether single nucleotide polymorphisms associated with WMH in community populations were associated with magnetic resonance imaging-confirmed lacunar stroke (n=1,373), as well as cardioembolic (n=1,331) and large vessel (n=1,472) Trial of Org 10172 in Acute Stroke Treatment subtypes, against 9,053 control..
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Awarded by Menzies Centre for Australian Studies, King's College London, University of London
Funding Acknowledgements
H. Markus was supported by an National Institure for Health Research (NIHR) Senior Investigator award. H. Markus and Dr Bevan were supported by the NIHR Cambridge University Hospitals Comprehensive Biomedical Research Centre. Collection of the UK Young Lacunar Stroke Resource was primarily supported by the Wellcome Trust (WT072952) with additional support from the Stroke Association (TSA 2010/01). Genotyping and Dr Traylor were supported by a project grant from the Stroke Association (TSA 2013/01). The research was also supported by the NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London. Dr Thijs was supported by a Flemish Fund of Scientific Research (FWO) Clinical Investigator Grant.