Journal article
Short bowel syndrome (SBS)-associated alterations within the gut-liver axis evolve early and persist long-term in the piglet model of short bowel syndrome
PM Pereira-Fantini, JE Bines, S Lapthorne, F Fouhy, M Scurr, PD Cotter, CGM Gahan, SA Joyce
Journal of Gastroenterology and Hepatology Australia | Published : 2016
DOI: 10.1111/jgh.13383
Abstract
Background and Aim: Short bowel syndrome (SBS) is primarily characterized by malabsorption and malnutrition, resulting from loss of intestinal absorptive area following massive small bowel resection (SBR). Bile acids and the gut microbiota are functionally linked within the gut-liver axis; however, SBS-associated disturbances within the gut-liver axis remain largely unexplored. The aim of this study was to characterize the evolution of bile acid alterations within the gut-liver axis at both short-term and long-term time points and to relate these changes to alterations in colonic bacterial composition. Methods: Four-week-old piglets were assigned to 75% SBR, sham-operation or non-operation c..
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Awarded by Irish Research Council for Science, Engineering and Technology
Funding Acknowledgements
The MCRI is supported by the Victorian Government's Operational Infrastructure Support program. The Cotter, Gahan, and Joyce laboratories are funded by a research grant from Science Foundation Ireland (SFI) under Grant Number SFI/12/RC/2273. FF is in receipt of an Irish Research Council for Science, Engineering and Technology EMBARK scholarship and is a Teagasc Walsh fellow. The authors wish to acknowledge Dr. Guin Wilson for her surgical skill, Professors Catherine Stanton, Gerald Fitzgerald, and Paul Ross for their continued support and to thank Magdy Sourial, Shane Osterfield, and Dr. Andrew French for expert technical assistance with the animals, and Dr. Jean-Pierre Scheerlinck and The University of Melbourne Centre for Animal Biotechnology for the use of their facilities, and Dr. Eva Rosberg-Cody and Dr Orla O'Sullivan for high-throughput DNA sequencing services. Dr. Mike Kinsella and Dr. Dan O Driscoll for UPLC-MS services.