Journal article

Risk factors for Plasmodium falciparum and Plasmodium vivax gametocyte carriage in Papua New Guinean children with uncomplicated malaria

Stephan Karl, Moses Laman, Brioni R Moore, John M Benjamin, Mary Salib, Lina Lorry, Samuel Maripal, Peter Siba, Leanne J Robinson, Ivo Mueller, Timothy ME Davis

ACTA TROPICA | ELSEVIER | Published : 2016


There are limited data on gametocytaemia risk factors before/after treatment with artemisinin combination therapy in children from areas with transmission of multiple Plasmodium species. We utilised data from a randomised trial comparing artemether-lumefantrine (AL) and artemisinin-naphthoquine (AN) in 230 Papua New Guinean children aged 0.5-5 years with uncomplicated malaria in whom determinants of gametocytaemia by light microscopy were assessed at baseline using logistic regression and during follow-up using multilevel mixed effects modelling. Seventy-four (32%) and 18 (8%) children presented with P. falciparum and P. vivax gametocytaemia, respectively. Baseline P. falciparum gametocytaem..

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Awarded by NHMRC

Awarded by TMED an NHMRC Practitioner Fellowship

Funding Acknowledgements

We would like to acknowledge the children who participated in these studies and their parents/guardians. This study was funded in part by an NHMRC project grant (#634343). SK is supported through an NHMRC early career fellowship (#1052960), ML was supported by an Australian Award PhD Scholarship, BRM by a NHMRC Early Career Fellowship (#1036951), LJR a NHMRC Early Career Fellowship (#1016443), IM a NHMRC Senior Research Fellowship (#1043345) and TMED an NHMRC Practitioner Fellowship (#572561 and #1058260). None of the sponsors had a role in study design, in the collection, analysis and interpretation of data, in the writing of the report, and in the decision to submit the article for publication.