Risk factors for Plasmodium falciparum and Plasmodium vivax gametocyte carriage in Papua New Guinean children with uncomplicated malaria
Stephan Karl, Moses Laman, Brioni R Moore, John M Benjamin, Mary Salib, Lina Lorry, Samuel Maripal, Peter Siba, Leanne J Robinson, Ivo Mueller, Timothy ME Davis
ACTA TROPICA | ELSEVIER | Published : 2016
There are limited data on gametocytaemia risk factors before/after treatment with artemisinin combination therapy in children from areas with transmission of multiple Plasmodium species. We utilised data from a randomised trial comparing artemether-lumefantrine (AL) and artemisinin-naphthoquine (AN) in 230 Papua New Guinean children aged 0.5-5 years with uncomplicated malaria in whom determinants of gametocytaemia by light microscopy were assessed at baseline using logistic regression and during follow-up using multilevel mixed effects modelling. Seventy-four (32%) and 18 (8%) children presented with P. falciparum and P. vivax gametocytaemia, respectively. Baseline P. falciparum gametocytaem..View full abstract
Awarded by NHMRC
Awarded by TMED an NHMRC Practitioner Fellowship
We would like to acknowledge the children who participated in these studies and their parents/guardians. This study was funded in part by an NHMRC project grant (#634343). SK is supported through an NHMRC early career fellowship (#1052960), ML was supported by an Australian Award PhD Scholarship, BRM by a NHMRC Early Career Fellowship (#1036951), LJR a NHMRC Early Career Fellowship (#1016443), IM a NHMRC Senior Research Fellowship (#1043345) and TMED an NHMRC Practitioner Fellowship (#572561 and #1058260). None of the sponsors had a role in study design, in the collection, analysis and interpretation of data, in the writing of the report, and in the decision to submit the article for publication.