Targeted therapeutic mild hypercapnia after cardiac arrest: A phase II multi-centre randomised controlled trial (the CCC trial)

Glenn M Eastwood; Antoine G Schneider; Satoshi Suzuki; Leah Peck; Helen Young; Aiko Tanaka; Johan Martensson; Stephen Warrillow; Shay McGuinness; Rachael Parke; Eileen Gilder; Lianne Mccarthy; Pauline Galt; Gopal Taori; Suzanne Eliott; Tammy Lamac; Michael Bailey; Nerina Harley; Deborah Barge; Carol L Hodgson; Maria Cristina Morganti-Kossmann; Alice Pebay; Alison Conquest; John S Archer; Stephen Bernard; Dion Stub; Graeme K Hart; Rinaldo Bellomo

Journal article

Targeted therapeutic mild hypercapnia after cardiac arrest: A phase II multi-centre randomised controlled trial (the CCC trial)

Glenn M Eastwood, Antoine G Schneider, Satoshi Suzuki, Leah Peck, Helen Young, Aiko Tanaka, Johan Martensson, Stephen Warrillow, Shay McGuinness, Rachael Parke, Eileen Gilder, Lianne Mccarthy, Pauline Galt, Gopal Taori, Suzanne Eliott, Tammy Lamac, Michael Bailey, Nerina Harley, Deborah Barge, Carol L Hodgson Show all

RESUSCITATION | ELSEVIER IRELAND LTD | Published : 2016

DOI: 10.1016/j.resuscitation.2016.03.023

Abstract

BACKGROUND: In intensive care observational studies, hypercapnia after cardiac arrest (CA) is independently associated with improved neurological outcome. However, the safety and feasibility of delivering targeted therapeutic mild hypercapnia (TTMH) for such patients is untested. METHODS: In a phase II safety and feasibility multi-centre, randomised controlled trial, we allocated ICU patients after CA to 24h of targeted normocapnia (TN) (PaCO2 35-45mmHg) or TTMH (PaCO2 50-55mmHg). The primary outcome was serum neuron specific enolase (NSE) and S100b protein concentrations over the first 72h assessed in the first 50 patients surviving to day three. Secondary end-points included global measure..

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University of Melbourne Researchers

John Archer Author Medicine - Austin Health

Rinaldo Bellomo Author Critical Care

Alice Pebay Author Surgery - Royal Melbourne Hospital

Graeme Hart Author Surgery - Austin Health

Glenn Eastwood Author Critical Care

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Grants

Funding Acknowledgements

The trial was supported by the Australian and New Zealand Intensive Care Society Clinical Trials Group (ANZICS Clinical Trials Group). Funding support was also received from the Anaesthesia Intensive Care Trust Fund (Austin Hospital, Melbourne); Intensive Care Foundation; Ambulance Victoria; Austin Medical Research Foundation; and, Green Lane Research and Educational Fund Board, Auckland City Hospital. Laerdal Foundation Project Grant 2015. Funding bodies did not have input into the design, management or reporting of the trial.