Obstructive Sleep Apnea Treatment and Atrial Fibrillation: A Need for Definitive Evidence
Chrishan J Nalliah, Prashanthan Sanders, Jonathan M Kalman
Journal of Cardiovascular Electrophysiology | WILEY | Published : 2016
Prevalence rates of atrial fibrillation (AF) and obstructive sleep apnea (OSA) are rising on a global scale. Epidemiological data have consistently demonstrated an independent association between the 2 conditions. Investigators pose that pathophysiologic features of OSA enable progression of the AF substrate; these features include abnormalities of gas exchange, autonomic remodeling, atrial stretch, and inflammation. Furthermore, many of the mechanistic perturbations that impact the AF substrate in OSA can be substantially attenuated by effective treatment with continuous positive airway pressure (CPAP). Clear associations of OSA treatment and improved AF control have been observed across mu..View full abstract
Dr. Nalliah is supported by a Postgraduate Scholarship from the National Health and Medical Research Council of Australia and The National Heart Foundation of Australia. Dr. Nalliah is also supported by the B.J Amos Travelling Fellowship from the Westmead Association Westmead Hospital. Drs. Kalman and Sanders are supported by Practitioner Fellowships from the National Health and Medical Research Council of Australia. Dr. Sanders is supported by the National Heart Foundation of Australia.Dr. Kalman reports having received research funding from St. Jude Medical, Biosense-Webster, Medtronic, and Boston Scientific. Dr. Sanders reports having served on the advisory board of Biosense-Webster, Medtronic, St. Jude Medical, Sanofi-Aventis, and Merck, Sharpe and Dohme; having received lecture and/or consulting fees from Biosense-Webster, Medtronic, St. Jude Medical, Boston Scientific, Merck, Sharpe and Dohme, Biotronik, and Sanofi-Aventis; having received research funding from Medtronic, St. Jude Medical, Boston Scientific, Biotronik, and Sorin.