Journal article
Effect of adrenaline on survival in out-of-hospital cardiac arrest: A randomised double-blind placebo-controlled trial
IG Jacobs, JC Finn, GA Jelinek, HF Oxer, PL Thompson
Resuscitation | ELSEVIER IRELAND LTD | Published : 2011
Abstract
Background: There is little evidence from clinical trials that the use of adrenaline (epinephrine) in treating cardiac arrest improves survival, despite adrenaline being considered standard of care for many decades. The aim of our study was to determine the effect of adrenaline on patient survival to hospital discharge in out of hospital cardiac arrest. Methods: We conducted a double blind randomised placebo-controlled trial of adrenaline in out-of-hospital cardiac arrest. Identical study vials containing either adrenaline 1:1000 or placebo (sodium chloride 0.9%) were prepared. Patients were randomly allocated to receive 1. ml aliquots of the trial drug according to current advanced life sup..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The investigators would like to acknowledge the support of St John Ambulance Western Australia and the paramedics who were willing to participate in the study. Appreciation is extended to: Pharma Laboratories who prepared the adrenaline and placebo vials; to and Laraine Salo and Tena Rowe who undertook data entry; and to Dr Tiew-Hwa Teng who derived the CPC scores. This study was funded by the National Health and Medical Research Council (Grant No. 254537). The funding body had no involvement in any aspect of study design, conduct or analysis. The results of this study were presented at the American Heart Association Resuscitation Science Symposium in Chicago in 2010 and the European Resuscitation Council Resuscitation Congress 2010 in Porto.