Journal article

Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes

Christopher D Goodman, Josephine E Siregar, Vanessa Mollard, Joel Vega-Rodriguez, Din Syafruddin, Hiroyuki Matsuoka, Motomichi Matsuzaki, Tomoko Toyama, Angelika Sturm, Anton Cozijnsen, Marcelo Jacobs-Lorena, Kiyoshi Kita, Sangkot Marzuki, Geoffrey I McFadden

Science | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2016

Grants

Awarded by U.S. National Institutes of Health


Awarded by Japanese Society for Promotion of Science (JSPS) KAKENHI


Awarded by Japanese Science and Technology Agency/Japan International Cooperation Agency Science and Technology Research Partnership for Sustainable Development (SATREPS)


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This work was supported by grants from the National Health and Medical Research Council (Australia); the Australian Research Council; the Indonesian Ministry of Research, Technology, and Higher Education; the U.S. National Institutes of Health (grants AI031478 and RR00052); the Japanese Society for Promotion of Science (JSPS) KAKENHI (grant 23117004 to M. M. and 26253025 to K. K.); and Japanese Science and Technology Agency/Japan International Cooperation Agency Science and Technology Research Partnership for Sustainable Development (SATREPS; no. 10000284 to K. K.). We acknowledge support of the Program for Promotion of Basic and Applied Researches for Innovations in Bio-oriented Industry (BRAIN) and the Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries and Food Industry. J.E.S. was a JSPS Ph.D. fellow (RONPAKU program) and an Endeavor Fellow from Scope Global, Australia. A.S. is affiliated with TropIQ Health Sciences (http://tropiq.nl). We thank the Johns Hopkins Malaria Research Institute mosquito and parasite core facilities for help with mosquito rearing and P. falciparum cultures, S. Narulitha of the Eijkman Institute for Molecular Biology for the novel P. berghei PbM133I atovaquone resistance mutant, and Walter Reed Army Institute of Research for the P. falciparum NF54e parasites. Data are archived at figshare (https://figshare.com) under doi 10.4225/49/56DE29B278684.