Journal article
Associations between DNA damage, DNA base excision repair gene variability and Alzheimer's disease risk
D Kwiatkowski, P Czarny, M Toma, N Jurkowska, A Sliwinska, J Drzewoski, A Bachurska, J Szemraj, M Maes, M Berk, KP Su, P Galecki, T Sliwinski
Dementia and Geriatric Cognitive Disorders | Published : 2016
DOI: 10.1159/000443953
Abstract
Background: Increased oxidative damage to DNA is one of the pathways involved in Alzheimer's disease (AD). Insufficient base excision repair (BER) is in part responsible for increased oxidative DNA damage. The aim of the present study was to assess the effect of polymorphic variants of BER-involved genes and the peripheral markers of DNA damage and repair in patients with AD. Material and Methods: Comet assays and TaqMan probes were used to assess DNA damage, BER efficiency and polymorphic variants of 12 BER genes in blood samples from 105 AD patients and 130 controls. The DNA repair efficacy (DRE) was calculated according to a specific equation. Results: The levels of endogenous and oxidati..
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Awarded by Polish National Science Centre
Funding Acknowledgements
This study was supported with funding from the scientific research grant from the Polish National Science Centre (No. DEC-2012/05/B/NZ7/03032).