Journal article
Pro-inflammatory self-reactive T cells are found within murine TCR-αβ CD4−CD8−PD-1 cells
N Rodríguez-Rodríguez, SA Apostolidis, L Fitzgerald, BS Meehan, AJ Corbett, JM Martín-Villa, J McCluskey, GC Tsokos, JC Crispín
European Journal of Immunology | Published : 2016
Abstract
TCR-αβ+ double negative (DN) T cells (CD3+TCR-αβ+CD4−CD8−NK1.1−CD49b−) represent a minor heterogeneous population in healthy humans and mice. These cells have been ascribed pro-inflammatory and regulatory capacities and are known to expand during the course of several autoimmune diseases. Importantly, previous studies have shown that self-reactive CD8+ T cells become DN after activation by self-antigens, suggesting that self-reactive T cells may exist within the DN T-cell population. Here, we demonstrate that programmed cell death 1 (PD-1) expression in unmanipulated mice identifies a subset of DN T cells with expression of activation-associated markers and a phenotype that strongly suggests..
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Awarded by National Institutes of Health
Funding Acknowledgements
[ "We acknowledge the NIH Tetramer Core Facility (contract HHSN272201300006C) for provision of CD1d-tetramers. We are grateful to Drs. Christophe Benoist, Lydia Lynch, and Dennis Kasper for providing several strains of mice.", "This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21 AR063262) (J.C.C.) and by the National Institute of Allergy and Infectious Diseases (R01 AI085567) (G.C.T.) of the National Institutes of Health, and by a grant from the Alliance for Lupus Research (J.C.C.). S.A.A. was supported by a Postdoctoral Fellowship Award from the Arthritis Foundation." ]