Journal article
Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine
MR Hudson, G Rind, TJ O'Brien, NC Jones
TRANSLATIONAL PSYCHIATRY | NATURE PUBLISHING GROUP | Published : 2016
DOI: 10.1038/tp.2016.51
Abstract
Recent heuristic models of schizophrenia propose that abnormalities in the gamma frequency cerebral oscillations may be closely tied to the pathophysiology of the disorder, with hypofunction of N-methyl-d-aspartate receptors (NMDAr) implicated as having a crucial role. Prepulse inhibition (PPI) is a behavioural measure of sensorimotor gating that is disrupted in schizophrenia. We tested the ability for antipsychotic drugs with diverse pharmacological actions to (1) ameliorate NMDAr antagonist-induced disruptions to gamma oscillations and (2) attenuate NMDAr antagonist-induced disruptions to PPI. We hypothesized that antipsychotic-mediated improvement of PPI deficits would be accompanied by a..
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Grants
Awarded by ARC
Awarded by NHMRC
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
This research was supported by the University of Melbourne research grant support scheme. NCJ received funding from the ARC Future Fellowship scheme (# 130100100) and from the NHMRC Career Development Award scheme (# 628466) to support this work. TJO and NCJ received funding from the NHMRC project grant scheme for this work (# 566843 and # 1059860).