Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine
MR Hudson, G Rind, TJ O'Brien, NC Jones
TRANSLATIONAL PSYCHIATRY | NATURE PUBLISHING GROUP | Published : 2016
Recent heuristic models of schizophrenia propose that abnormalities in the gamma frequency cerebral oscillations may be closely tied to the pathophysiology of the disorder, with hypofunction of N-methyl-d-aspartate receptors (NMDAr) implicated as having a crucial role. Prepulse inhibition (PPI) is a behavioural measure of sensorimotor gating that is disrupted in schizophrenia. We tested the ability for antipsychotic drugs with diverse pharmacological actions to (1) ameliorate NMDAr antagonist-induced disruptions to gamma oscillations and (2) attenuate NMDAr antagonist-induced disruptions to PPI. We hypothesized that antipsychotic-mediated improvement of PPI deficits would be accompanied by a..View full abstract
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Awarded by ARC
Awarded by NHMRC
This research was supported by the University of Melbourne research grant support scheme. NCJ received funding from the ARC Future Fellowship scheme (# 130100100) and from the NHMRC Career Development Award scheme (# 628466) to support this work. TJO and NCJ received funding from the NHMRC project grant scheme for this work (# 566843 and # 1059860).