Journal article

Breaking Up Prolonged Sitting With Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study

Joseph Henson, Melanie J Davies, Danielle H Bodicoat, Charlotte L Edwardson, Jason MR Gill, David J Stensel, Keith Tolfrey, David W Dunstan, Kamlesh Khunti, Thomas Yates



OBJECTIVE: To determine whether breaking up prolonged sitting with short bouts of standing or walking improves postprandial markers of cardiometabolic health in women at high risk of type 2 diabetes. RESEARCH DESIGN AND METHODS: Twenty-two overweight/obese, dysglycemic, postmenopausal women (mean ± SD age 66.6 ± 4.7 years) each participated in two of the following treatments: prolonged, unbroken sitting (7.5 h) or prolonged sitting broken up with either standing or walking at a self-perceived light intensity (for 5 min every 30 min). Both allocation and treatment order were randomized. The incremental area under the curves (iAUCs) for glucose, insulin, nonesterified fatty acids (NEFA), and t..

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University of Melbourne Researchers


Funding Acknowledgements

The research was supported by the National Institute for Health Research (NIHR) Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, which is a partnership between University Hospitals of Leicester National Health Service Trust, Loughborough University, and the University of Leicester; NIHR Collaborations for Leadership in Applied Health Research and Care, Leicestershire, Northamptonshire, and Rutland (NIHR CLAHRC-LNR) and East Midlands (NIHR CLAHRC EM); and the University of Leicester Clinical Trials Unit.