Journal article

Increased Hippocampus-Medial Prefrontal Cortex Resting-State Functional Connectivity and Memory Function after Tai Chi chuan Practice in Elder Adults

Jing Tao, Jiao Liu, Natalia Egorova, Xiangli Chen, Sharon Sun, Xiehua Xue, Jia Huang, Guohua Zheng, Qin Wang, Lidian Chen, Jian Kong



Previous studies provide evidence that aging is associated with the decline of memory function and alterations in the hippocampal (HPC) function, including functional connectivity to the medial prefrontal cortex (mPFC). In this study, we investigated if longitudinal (12-week) Tai Chi Chuan and Baduanjin practice can improve memory function and modulate HPC resting-state functional connectivity (rs-FC). Memory function measurements and resting-state functional magnetic resonance imaging (rs-fMRI) were applied at the beginning and the end of the experiment. The results showed that (1) the memory quotient (MQ) measured by the Wechsler Memory Scale-Chinese Revision significantly increased after ..

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Awarded by Special Scientific Research Fund of Public Welfare Profession of China

Awarded by Fujian Rehabilitation Tech Co-Innovation Center

Awarded by NIH/NCCIH

Awarded by National Center for Complementary & Integrative Health

Funding Acknowledgements

This study is supported by the Special Scientific Research Fund of Public Welfare Profession of China (Grant No. 201307004), Ministry of Science and Technology and Ministry of Finance of the People's Republic of China, National Rehabilitation Research Center of Traditional Chinese Medicine, Fujian Provincial Rehabilitation Industrial Institution, and Fujian Rehabilitation Tech Co-Innovation Center (Grant No. X2012007-Collaboration). JK is supported by R01AT006364 (NIH/NCCIH), R01 AT008563 (NIH/NCCIH), R21AT008707 (NIH/NCCIH), and P01 AT006663 (NIH/NCCIH). We thank the Joel Park from MGH for English editing.