Journal article

The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients

Xiaoyan Chen, Rosa B Spaeth, Sonya G Freeman, Donna Moxley Scarborough, Javeria A Hashmi, Hsiao-Ying Wey, Natalia Egorova, Mark Vangel, Jianren Mao, Ajay D Wasan, Robert R Edwards, Randy L Gollub, Jian Kong

MOLECULAR PAIN | SAGE PUBLICATIONS INC | Published : 2015

Abstract

UNLABELLED: Recent advances in brain imaging have contributed to our understanding of the neural activity associated with acupuncture treatment. In this study, we investigated functional connectivity across longitudinal acupuncture treatments in older patients with knee osteoarthritis (OA). Over a period of 4 weeks (six treatments), we collected resting state functional magnetic resonance imaging (fMRI) scans from 30 patients before and after their first, third and sixth treatments. Clinical outcome showed a significantly greater pain subscore on the Knee Injury and Osteoarthritis Outcome Score (KOOS) (indicative of improvement) with verum acupuncture than with sham acupuncture. Independent ..

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