Journal article
The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients
X Chen, RB Spaeth, SG Freeman, DM Scarborough, JA Hashmi, HY Wey, N Egorova, M Vangel, J Mao, AD Wasan, RR Edwards, RL Gollub, J Kong
Molecular pain | Published : 2015
Abstract
UNLABELLED: Recent advances in brain imaging have contributed to our understanding of the neural activity associated with acupuncture treatment. In this study, we investigated functional connectivity across longitudinal acupuncture treatments in older patients with knee osteoarthritis (OA). Over a period of 4 weeks (six treatments), we collected resting state functional magnetic resonance imaging (fMRI) scans from 30 patients before and after their first, third and sixth treatments. Clinical outcome showed a significantly greater pain subscore on the Knee Injury and Osteoarthritis Outcome Score (KOOS) (indicative of improvement) with verum acupuncture than with sham acupuncture. Independent ..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by R21AT004497 (NIH/NCCIH), R03AT218317 (NIH/NIDA), R01AT006364 (NIH/NCCIH), R01AT008563 (NIH/NCCIH) to Jian Kong, R01AT005280 (NCCIH) to Randy Gollub, and P01 AT006663 to Bruce Rosen.