Journal article

Repeated verumbut not placebo acupuncture normalizes connectivity in brain regions dysregulated in chronic pain

Natalia Egorova, Randy L Gollub, Jian Kong

NEUROIMAGE-CLINICAL | ELSEVIER SCI LTD | Published : 2015

Abstract

Acupuncture, an ancient East Asian therapy, is aimed at rectifying the imbalance within the body caused by disease. Studies evaluating the efficacy of acupuncture with neuroimaging tend to concentrate on brain regions within the pain matrix, associated with acute pain. We, however, focused on the effect of repeated acupuncture treatment specifically on brain regions known to support functions dysregulated in chronic pain disorders. Transition to chronic pain is associated with increased attention to pain, emotional rumination, nociceptive memory and avoidance learning, resulting in brain connectivity changes, specifically affecting the periaqueductal gray (PAG), medial frontal cortex (MFC) a..

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Grants

Awarded by NCCIH


Awarded by NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE


Awarded by NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE


Awarded by National Center for Complementary & Integrative Health


Funding Acknowledgements

This work was supported by R21AT004497 (NCCIH), RO1AT00634 and R01AT008563 (NCCIH) to Jian Kong, RO1AT005280 (NCCIH) to Randy Gollub, and P01AT006663 to Bruce Rosen. The authors declare no conflict of interest.