Distinct neural representations of placebo and nocebo effects
Sonya Freeman, Rongjun Yu, Natalia Egorova, Xiaoyan Chen, Irving Kirsch, Brian Claggett, Ted J Kaptchuk, Randy L Gollub, Jian Kong
NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2015
Expectations shape the way we experience the world. In this study, we used fMRI to investigate how positive and negative expectation can change pain experiences in the same cohort of subjects. We first manipulated subjects' treatment expectation of the effectiveness of three inert creams, with one cream labeled "Lidocaine" (positive expectancy), one labeled "Capsaicin" (negative expectancy) and one labeled "Neutral" by surreptitiously decreasing, increasing, or not changing respectively, the intensity of the noxious stimuli administered following cream application. We then used fMRI to investigate the signal changes associated with administration of identical pain stimuli before and after th..View full abstract
Awarded by NCCAM
Awarded by NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE
Awarded by National Center for Complementary & Integrative Health
This work was supported by R01AT006364 (NCCAM) to Jian Kong, R01AT005280 (NCCAM) to Randy Gollub, and P01 AT006663 to Bruce Rosen.