Thesis / Dissertation
Investigating the laser-induced model of choroidal neovascularisation in the Long Evans rat
S PREA, BV BUI (ed.), AJ VINGRYS (ed.), GJ DUSTING (ed.), GS LIU (ed.)
Published : 2016
Abstract
Laser-induced choroidal neovascularisation (LI CNV) involves delivering laser energy to the retina to produce a breach in Bruch’s membrane (BM). Elevation of pro-angiogenic and inflammatory cytokines in addition to extracellular matrix remodelling promotes the ingrowth of CNV following breach. A review of CNV, the effect of laser on the retina, and LI CNV is given in Chapter 2. Calibration of laser and all experimental methods are dealt with in Chapter 3. The dose-response of laser energy for BM breach is investigated in experimental Chapter 4 along with non-invasive measures of BM rupture. The minimum laser energy required for successful breach of BM on 95% of occasions was determined. The ..
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