Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma
Smitha R Georgy, Michael Cangkrama, Seema Srivastava, Darren Partridge, Alana Auden, Sebastian Dworkin, Catriona A McLean, Stephen M Jane, Charbel Darido
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | OXFORD UNIV PRESS INC | Published : 2015
BACKGROUND: The developmental transcription factor Grainyhead-like 3 (GRHL3) plays a critical tumor suppressor role in the mammalian epidermis through direct regulation of PTEN and the PI3K/AKT/mTOR signaling pathway. GRHL3 is highly expressed in all tissues derived from the surface ectoderm, including the oral cavity, raising a question about its potential role in suppression of head and neck squamous cell carcinoma (HNSCC). METHODS: We explored the tumor suppressor role of Grhl3 in HNSCC using a conditional knockout (Grhl3 (∆/-) /K14Cre (+) ) mouse line (n = 26) exposed to an oral chemical carcinogen. We defined the proto-oncogenic pathway activated in the HNSCC derived from these mice and..View full abstract
Awarded by Australian National Health and Medical Research Council
Awarded by Worldwide Cancer Research
This work was supported by grants from the Australian National Health and Medical Research Council (1049870 to SMJ) and the Association for International Cancer Research (to SMJ and CD).