Journal article
Evidence of a Causal Association between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis
KT Nead, SJ Sharp, DJ Thompson, JN Painter, DB Savage, RK Semple, A Barker, JRB Perry, J Attia, AM Dunning, DF Easton, E Holliday, LA Lotta, T O'Mara, M McEvoy, PDP Pharoah, RJ Scott, AB Spurdle, C Langenberg, NJ Wareham Show all
Journal of the National Cancer Institute | OXFORD UNIV PRESS INC | Published : 2015
DOI: 10.1093/jnci/djv178
Abstract
Background: Insulinemia and type 2 diabetes (T2D) have been associated with endometrial cancer risk in numerous observational studies. However, the causality of these associations is uncertain. Here we use a Mendelian randomization (MR) approach to assess whether insulinemia and T2D are causally associated with endometrial cancer. Methods: We used single nucleotide polymorphisms (SNPs) associated with T2D (49 variants), fasting glucose (36 variants), fasting insulin (18 variants), early insulin secretion (17 variants), and body mass index (BMI) (32 variants) as instrumental variables in MR analyses. We calculated MR estimates for each risk factor with endometrial cancer using an inverse-vari..
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Awarded by European Commission
Funding Acknowledgements
This work was supported by grants from the Australian National Health and Medical Research Council (1049870 to SMJ) and the Association for International Cancer Research (to SMJ and CD).