Journal article
Leptin in bipolar disorder: A systematic review and meta-analysis
BS Fernandes, S Dash, F Jacka, S Dodd, AF Carvalho, CA Köhler, J Steiner, M da Graça Cantarelli, P Nardin, CA Gonçalves, M Berk
European Psychiatry | Published : 2016
Abstract
Background: Bipolar disorder (BD) is a psychiatric disorder associated with increased rates of obesity and inflammation. Leptin is an adipokine that is mainly produced by the white adipose tissue in response to insulin. It stimulates the immune system, increasing the production of pro-inflammatory cytokines. There is currently uncertainty regarding possible alterations in peripheral leptin levels across the mood states in BD. Methods: This study comprises a between-group meta-analysis comparing serum and plasma leptin levels in people with BD in mania, depression or euthymia and healthy controls. We conducted a systematic search for all possibly eligible-English and non-English peer-reviewed..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
BSF is supported by a postdoctoral scholarship and by a research grant MCTI/CNPQ/Universal 14/2014461833/2014-0, both from CNPq, Brazil. CAK is a recipient of a postdoctoral fellowship from CAPES, Brazil. AFC is the recipient of a research fellowship from CNPq (Brazil, level II). MB is supported by a NHMRC Senior Principal Research Fellowship 1059660.