Journal article
Dissociating the therapeutic effects of environmental enrichment and exercise in a mouse model of anxiety with cognitive impairment
J Rogers, U Vo, LS Buret, TY Pang, H Meiklejohn, A Zeleznikow-Johnston, L Churilov, M Van Den Buuse, AJ Hannan, T Renoir
Translational Psychiatry | Published : 2016
DOI: 10.1038/tp.2016.52
Abstract
Clinical evidence indicates that serotonin-1A receptor (5-HT1AR) gene polymorphisms are associated with anxiety disorders and deficits in cognition. In animal models, exercise (Ex) and environmental enrichment (EE) can change emotionality-related behaviours, as well as enhance some aspects of cognition and hippocampal neurogenesis. We investigated the effects of Ex and EE (which does not include running wheels) on cognition and anxiety-like behaviours in wild-type (WT) and 5-HT1AR knock-out (KO) mice. Using an algorithm-based classification of search strategies in the Morris water maze, we report for we believe the first time that Ex increased the odds for mice to select more hippocampal-dep..
View full abstractGrants
Funding Acknowledgements
We thank Dr M Ransome for technical assistance (BrdU and Ki67 immunochemistry), as well as Tine Pooters for help in implementing our water maze cue set-up. We also thank Drs A Garthe and G Kempermann for providing the MATLAB script, as well as Matt Hudson for helping to analyse the search strategy in the Morris water maze. This work was supported by an ARC FT3 Future Fellowship (AJH) and ARC Discovery Early Career Research Award (TR). AJH is a NHMRC Senior Research Fellow. The Florey Institute of Neuroscience and Mental Health acknowledge the support from the Victorian Government's Operational Infrastructure Support Grant.