MicroRNAs of Toxocara canis and their predicted functional roles

Guangxu Ma; Yongfang Luo; Honghong Zhu; Yongli Luo; Pasi K Korhonen; Neil D Young; Robin B Gasser; Rongqiong Zhou

Journal article

MicroRNAs of Toxocara canis and their predicted functional roles

Guangxu Ma, Yongfang Luo, Honghong Zhu, Yongli Luo, Pasi K Korhonen, Neil D Young, Robin B Gasser, Rongqiong Zhou

PARASITES & VECTORS | BMC | Published : 2016

DOI: 10.1186/s13071-016-1508-3

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Abstract

BACKGROUND: Toxocara canis is the causative agent of toxocariasis of humans and other animals. This parasitic nematode (roundworm) has a complex life cycle, in which substantial developmental changes and switches occur. As small non-coding RNAs (sRNAs) are key regulators of gene expression in a wide range of organisms, we explored these RNAs in T. canis to provide a basis for future studies of its developmental biology as well as host interactions and disease at the molecular level. METHODS: We conducted high-throughput RNA sequencing and bioinformatic analyses to define sRNAs in individual male and female adults of T. canis. RESULTS: Apart from snRNA and snoRNA, 560 and 619 microRNAs (miRNA..

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University of Melbourne Researchers

Robin B. Gasser Author Veterinary Biosciences

Pasi Korhonen Author Veterinary Biosciences

Neil Young Author Veterinary Biosciences

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Grants

Awarded by National Natural Science Foundation of China

Awarded by International Science & Technology Cooperation Program of China

Funding Acknowledgements

This work was supported by the National Natural Science Foundation of China (no. 31172313), the Youth Fund Project (2015) of Southwest University Rongchang Campus and the International Science & Technology Cooperation Program of China (Grant No. 2013DFA31840). RBG's research is supported principally by grants from the National Health and Medical Research Council (NHMRC), Australian Research Council (ARC), Wellcome Trust, Melbourne Water Corporation and Yourgene Biosciences (Dr Bill Chang). BGI-Shenzhen (China) provided sequencing service.