Journal article

Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

Laura K Mackay, Martina Minnich, Natasja AM Kragten, Yang Liao, Benjamin Nota, Cyril Seillet, Ali Zaid, Kevin Man, Simon Preston, David Freestone, Asolina Braun, Erica Wynne-Jones, Felix M Behr, Regina Stark, Daniel G Pellicci, Dale I Godfrey, Gabrielle T Belz, Marc Pellegrini, Thomas Gebhardt, Meinrad Busslinger Show all

Science | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2016

Grants

Awarded by ARC


Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by European Research Council from the European Community


Awarded by NHMRC


Awarded by Landsteiner Foundation of Blood Transfusion Research


Awarded by Vidi from The Netherlands Organization of Scientific Research


Funding Acknowledgements

We wish to thank L. Mackiewicz and R. Gloury for technical support and M. Jaritz for bioinformatics support. The data presented in this manuscript are tabulated in the main paper and in the supplementary materials. RNA and ChIP sequencing data have been made available under accession numbers GSE70813 and GSE79339 at GEO. Blimp1-Bio mice are available from M.B. under a material transfer agreement (MTA) with IMP, Blimp1 KO, Blimp1-GFP and Blimp1 x Hobit DKO mice are available from A.K. under an MTA with The Walter and Eliza Hall Institute and Hobit KO and Blimp1 x Hobit DKO mice are available from K.P.J.M.v.G. under an MTA with Sanquin Research. L.K.M. was supported by grant DE140100432 from the ARC and grant 1083685 from the National Health and Medical Research Council of Australia (NHMRC). M.M. and M.B. were supported by the Boehringer Ingelheim and a European Research Council Advanced Grant (291740-LymphoControl) from the European Community's Seventh Framework Programme. A.B. was funded by a Fellowship from the German Research Foundation. R.S. was supported by a Fellowship from the Alexander von Humboldt Foundation. W.S. was supported by grant 1023454 from the NHMRC. N.A.M.K. and R.A.W.v.L. were supported by grant 1136 of the Landsteiner Foundation of Blood Transfusion Research. D.G.P. was supported by an NHMRC Early Career Fellowship (1054431), and D.I.G. was supported by an NHMRC Senior Principal Research Fellowship (1020770). G.T.B. was supported by a fellowship from the ARC and grant 1042582 from the NHMRC. A.K. was supported by a fellowship from the Sylvia and Charles Viertel Foundation and a project grant (637345) from the NHMRC. F.M.B. and K.P.J.M.v.G. were supported by Vidi grant 917.13.338 from The Netherlands Organization of Scientific Research. This work was supported by the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support scheme.