Journal article

Advances in targeted and immunobased therapies for colorectal cancer in the genomic era

Heng Fong Seow, Wai Kien Yip, Theodora Fifis

OncoTargets and Therapy | DOVE MEDICAL PRESS LTD | Published : 2016

Abstract

Targeted therapies require information on specific defective signaling pathways or mutations. Advances in genomic technologies and cell biology have led to identification of new therapeutic targets associated with signal-transduction pathways. Survival times of patients with colorectal cancer (CRC) can be extended with combinations of conventional cytotoxic agents and targeted therapies. Targeting EGFR- and VEGFR-signaling systems has been the major focus for treatment of metastatic CRC. However, there are still limitations in their clinical application, and new and better drug combinations are needed. This review provides information on EGFR and VEGF inhibitors, new therapeutic agents in th..

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University of Melbourne Researchers