Journal article
Amyloid burden and incident depressive symptoms in cognitively normal older adults
KD Harrington, E Gould, YY Lim, D Ames, RH Pietrzak, A Rembach, S Rainey-Smith, RN Martins, O Salvado, VL Villemagne, CC Rowe, CL Masters, P Maruff
International Journal of Geriatric Psychiatry | Published : 2017
DOI: 10.1002/gps.4489
Abstract
Objective: Several studies have reported that non-demented older adults with clinical depression show changes in amyloid-β (Aβ) levels in blood, cerebrospinal fluid and on neuroimaging that are consistent with those observed in patients with Alzheimer's disease. These findings suggest that Aβ may be one of the mechanisms underlying the relation between the two conditions. We sought to determine the relation between elevated cerebral Aβ and the presence of depression across a 54-month prospective observation period. Methods: Cognitively normal older adults from the Australian Imaging Biomarkers and Lifestyle study who were not depressed and had undergone a positron emission tomography scan to..
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Awarded by Australian Education International, Australian Government
Funding Acknowledgements
Funding for the study was provided in part by the study partners (Australian Commonwealth Scientific Industrial and Research Organization [CSIRO], Edith Cowan University [ECU], Mental Health Research Institute [MHRI], Alzheimer's Australia [AA], National Ageing Research Institute [NARI], Austin Health, CogState Ltd., Hollywood Private Hospital, Sir Charles Gardner Hospital). The study also received support from the National Health and Medical Research Council (NHMRC) and the Dementia Collaborative Research Centres program (DCRC2), as well as ongoing funding from the Science and Industry Endowment Fund (SIEF). The authors also acknowledge the financial support of the Cooperative Research Centre (CRC) for Mental Health, from the Australian Government.