Journal article
Inter-Seasonal Influenza is Characterized by Extended Virus Transmission and Persistence
Z Patterson Ross, N Komadina, YM Deng, N Spirason, HA Kelly, SG Sullivan, IG Barr, EC Holmes
Plos Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2015
Open access
Abstract
The factors that determine the characteristic seasonality of influenza remain enigmatic. Current models predict that occurrences of influenza outside the normal surveillance season within a temperate region largely reflect the importation of viruses from the alternate hemisphere or from equatorial regions in Asia. To help reveal the drivers of seasonality we investigated the origins and evolution of influenza viruses sampled during inter-seasonal periods in Australia. To this end we conducted an expansive phylogenetic analysis of 9912, 3804, and 3941 hemagglutinnin (HA) sequences from influenza A/H1N1pdm, A/H3N2, and B, respectively, collected globally during the period 2009-2014. Of the 147..
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Awarded by NHMRC Australia Fellowship
Funding Acknowledgements
ZPR is funded by an Australian Postgraduate Award (https://education.gov.au/australian-postgraduate-awards). ECH is funded by an NHMRC (http://www.nhmrc.gov.au/) Australia Fellowship (AF30). The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health (http://www.health.gov.au/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.