Sensitivity of HIV rapid tests compared with fourth-generation enzyme immunoassays or HIV RNA tests

WS Tan; EPF Chow; CK Fairley; MY Chen; CS Bradshaw; TRH Read

Journal article

Sensitivity of HIV rapid tests compared with fourth-generation enzyme immunoassays or HIV RNA tests

WS Tan, EPF Chow, CK Fairley, MY Chen, CS Bradshaw, TRH Read

AIDS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2016

DOI: 10.1097/QAD.0000000000001134

Abstract

Objective: Determine the sensitivity of HIV rapid tests compared with fourth-generation enzyme immunoassays (EIA) or nucleic acid amplification tests (NAAT) in clinical settings. Design: Systematic review and meta-analysis. Methods: Medline, PubMed, Embase, Cochrane Controlled Trials Register, Cochrane reviews and Cumulative Index to Nursing and Allied Health Literature were searched until 14 July 2015 for studies of adults comparing point-of-care HIV rapid tests to fourth-generation HIV EIA antibody/p24 antigen or HIV NAAT. Results: From 953 titles, 18 studies were included, involving 110122 HIV rapid test results. Compared with EIA, the estimated sensitivity (random effects) of HIV rapid t..

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University of Melbourne Researchers

Eric Chow Author

Catriona Bradshaw Author

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The Australian National Health and Medical Research Council supports EPFC and TRHR with Early Career Fellowships (EPCF No. 1091226, TRHR No. 1091536).