Journal article

Gait recovery following spinal cord injury in mice: Limited effect of treadmill training

Camila R Battistuzzo, Michelle M Rank, Jamie R Flynn, David L Morgan, Robin Callister, Robert J Callister, Mary P Galea

JOURNAL OF SPINAL CORD MEDICINE | TAYLOR & FRANCIS LTD | Published : 2016

Abstract

BACKGROUND: Several studies in rodents with complete spinal cord transections have demonstrated that treadmill training improves stepping movements. However, results from studies in incomplete spinal cord injured animals have been conflicting and questions regarding the training dosage after injury remain unresolved. OBJECTIVES: To assess the effects of treadmill-training regimen (20 minutes daily, 5 days a week) for 3, 6 or 9 weeks on the recovery of locomotion in hemisected SCI mice. METHODS: A randomized and blinded controlled experimental trial used a mouse model of incomplete spinal cord injury (SCI). After a left hemisection at T10, adult male mice were randomized to trained or untrain..

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