Modelling passive absorption properties of phytochemicals using physicochemical properties

Abstract

Dietary phytochemicals are associated with reducing risk of chronic diseases in humans. Protective bio-efficacy of phytochemicals depends on absorption in the digestive tract and consequent plasma concentrations of bioactive species, but methods to predict absorption of phytochemicals are lacking. Phytochemicals are structurally heterogeneous and the time to reach their maximum concentration in plasma (Tmax) reflects molecular properties and absorption via either the upper or lower intestine. We have developed two statistical models to predict Tmax of phytochemicals following intestinal passive absorption using selected physicochemical properties. The data used to develop the models was obta..