Ultrasound Assisted Crystallization of Paracetamol: Crystal Size Distribution and Polymorph Control
Sukhvir Kaur Bhangu, Muthupandian Ashokkumar, Judy Lee
CRYSTAL GROWTH & DESIGN | AMER CHEMICAL SOC | Published : 2016
Antisolvent crystallization of paracetamol was conducted using ultrasound. The effect of various ultrasonic frequencies and power on the mean crystal size, crystal size distribution, induction time, and type of polymorph obtained was studied. Multibubble sonoluminescence intensity was used to correlate the crystallization results with cavitation activity. Results showed that under optimum conditions ultrasound can significantly (i) reduce the mean crystal size from 170 to 13 μm, (ii) lower the induction time from 360 to 30 s, and (iii) narrow the size distribution. A close association between cavitation activity and rate of nucleation was observed. In addition, crystallization under sonicati..View full abstract
Awarded by Australian Research Council
The financial support through the Australian Research Council for the DECRA (Discovery Early Career Research Award DE120101567) is gratefully acknowledged.