Maternal plasma concentrations of the placental specific sFLT-1 variant, sFLT-1 e15a, in fetal growth restriction and preeclampsia
Kirsten R Palmer, Tu'uhevaha J Kaitu'u-Lino, Ping Cannon, Laura Tuohey, Manarangi S De Silva, Manuel Varas-Godoy, Stephanie Acuna, Jose Galaz, Stephen Tong, Sebastian E Illanes
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | TAYLOR & FRANCIS LTD | Published : 2017
OBJECTIVE: sFLT-1 e15a is a recently described sFlt-1 variant that is placental and primate specific. As such, it may have potential as a biomarker. Using a newly developed ELISA, we measured maternal plasma sFLT-1 e15a levels in women with fetal growth restriction and pre-eclampsia. METHOD: We performed a nested case-control study where we measured total sFLT-1 and sFLT-1 e15a plasma protein concentrations. Samples, selected from a prospective cohort study, consisted of 87 healthy controls, 11 cases that developed term preeclampsia and 20 cases where there was fetal growth restriction. We also measured sFLT-1 and sFLT-1 e15a plasma concentrations in a separate cohort: 15 cases of preterm pr..View full abstract
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Awarded by National Health and Medical Research Council of Australia
The authors report no declarations of interest. This work was supported by the National Health and Medical Research Council of Australia who provided grant (#1061977) and salary support (1062418, 1050765).