Journal article
Maternal mental well-being during pregnancy and glucocorticoid receptor gene promoter methylation in the neonate
T Mansell, P Vuillermin, AL Ponsonby, F Collier, R Saffery, J Ryan
Development and Psychopathology | CAMBRIDGE UNIV PRESS | Published : 2016
Abstract
Maternal mental health during pregnancy has been linked to health outcomes in progeny. Mounting evidence implicates fetal "programming" in this process, possibly via epigenetic disruption. Maternal mental health has been associated with glucocorticoid receptor methylation (nuclear receptor subfamily 3, group C, member 1 [NR3C1]) in the neonate; however, most studies have been small (n < 100) and have failed to control for multiple testing in the statistical analysis. The Barwon Infant Study is a population-derived birth cohort with antenatal recruitment. Maternal depression and anxiety were assessed using the Edinburgh Postnatal Depression Scale and psychological distress using the Perceived..
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Awarded by Murdoch Children's Research Institute
Funding Acknowledgements
The members of the Barwon Infant Study Investigator Team are the following: Peter Vuillermin, Barwon Health, Deakin University, the Murdoch Children's Research Institute, and University of Melbourne; Anne-Louise Ponsonby, John Carlin, Katie Allen, Mimi Tang, Richard Saffery, Sarath Ranganathan, and David Burgner, the Murdoch Children's Research Institute, University of Melbourne; Terry Dwyer, the Murdoch Children's Research Institute and the George Institute for Global Health; Kim Jachno, the Murdoch Children's Research Institute; and Peter Sly, University of Queensland, Queensland Children's Medical Research Institute. The Barwon Infant Study is supported by a National Health and Medical Research Council (NHMRC) project grant and the Victorian Government's Operational Infrastructure Support Program. This project was supported by the Preston and Loui Geduld Trust Fund, managed by Equity Trustees, and was partially supported by the Commission of the European Communities under the 7th Framework Programme (Contract FP7-289346-EARLY NUTRITION). This work was also supported through an Australian Postgraduate Award, University of Melbourne (to T.M.), NHMRC Senior Research Fellowships APP1008396 (to A.L.P.) and APP1045161 (to R.S.), and NHMRC Early Career Researcher Fellowship APP1012735 (to J.R.). We acknowledge and thank the Barwon Infant Study research staff and participants.