Journal article

No Relationship of Lipid-Lowering Agents to Hematoma Growth Pooled Analysis of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials Studies

Miriam Priglinger, Hisatomi Arima, Craig Anderson, Martin Krause

STROKE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015

Abstract

BACKGROUND AND PURPOSE: Controversy persists over statins and risk of intracerebral hemorrhage. We determined associations of premorbid lipid-lowering therapy and outcomes among participants of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials (INTERACT). METHODS: The pooled data of INTERACT 1 and 2 (international, multicenter, prospective, open, blinded end point, randomized controlled trials of patients with intracerebral hemorrhage [<6 hours] and elevated systolic blood pressure) were analyzed with regard to associations of baseline lipid-lowering treatment and clinical outcomes of 3184 participants in a multivariate model. Associations of lipid-lowering therapy a..

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