Journal article
Disseminated glioneuronal tumors occurring in childhood: treatment outcomes and BRAF alterations including V600E mutation
AJ Dodgshun, N SantaCruz, J Hwang, SH Ramkissoon, H Malkin, G Bergthold, P Manley, S Chi, D MacGregor, L Goumnerova, M Sullivan, K Ligon, R Beroukhim, B Herrington, MW Kieran, JR Hansford, P Bandopadhayay
Journal of Neuro Oncology | SPRINGER | Published : 2016
Abstract
Disseminated glioneuronal tumors of childhood are rare. We present a retrospective IRB-approved review of the clinical course and frequency of BRAF mutations in disseminated glioneuronal tumors at two institutions. Defining features of our cohort include diffuse leptomeningeal-spread, often with a discrete spinal cord nodule and oligodendroglioma-like histologic features. Patients were identified through a pathology database search of all cases with disseminated low-grade neoplasms with an oligodendroglioma-like component. De-identified clinical information was collected by chart review and all imaging was reviewed. We retrieved the results of targeted genomic analyses for alterations in BRA..
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Funding Acknowledgements
We acknowledge the following funding sources: A Kids' Brain Tumor Cure Foundation Pediatric Low-Grade Astrocytoma Foundation (PB, KLL, RB, MWK, LG), Stop and Shop Pediatric Brain Tumor Program (NSC, PB, MWK), St Baldrick's Foundation (PB), Team Jack Foundation (PB, MWK, RB, LG), Andrysiak Fund for LGG (MWK), Jared Branfman Sunflowers For Life Fund For Pediatric Brain And Spinal Cancer Research (PB, RB), Sontag Foundation (KLL, RB), Nuovo-Soldati Foundation (GB), Philippe Foundation (GB), Pediatric Brain Tumor Foundation (RB, PB), Royal Children's Hospital Foundation (JH), Robert Connor Dawes Foundation (JH), Dr. Dodgshun is the recipient of the Murray Jackson Clinical Fellowship, Genesis Oncology Trust, New Zealand.