Journal article

Difference in Restricted Mean Survival Time for Cost-Effectiveness Analysis Using Individual Patient Data Meta-Analysis: Evidence from a Case Study

Beranger Lueza, Audrey Mauguen, Jean-Pierre Pignon, Oliver Rivero-Arias, Julia Bonastre



OBJECTIVE: In economic evaluation, a commonly used outcome measure for the treatment effect is the between-arm difference in restricted mean survival time (rmstD). This study illustrates how different survival analysis methods can be used to estimate the rmstD for economic evaluation using individual patient data (IPD) meta-analysis. Our aim was to study if/how the choice of a method impacts on cost-effectiveness results. METHODS: We used IPD from the Meta-Analysis of Radiotherapy in Lung Cancer concerning 2,000 patients with locally advanced non-small cell lung cancer, included in ten trials. We considered methods either used in the field of meta-analysis or in economic evaluation but never..

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Funding Acknowledgements

This work was supported by ITMO Cancer and IReSP (French Public Health Research Institute) as part of the French "Plan Cancer 2009-2013", by the French "Programme Hospitalier de Recherche Clinique", and by the French "Ligue Nationale Contre le Cancer". The funding sources had no role in study design, data collection, data analysis, data interpretation, or manuscript writing.