miRNA expression profiling of cerebrospinal fluid in patients with aneurysmal subarachnoid hemorrhage
Stanley S Stylli, Alexios A Adamides, Rachel M Koldej, Rodney B Luwor, David S Ritchie, James Ziogas, Andrew H Kaye
JOURNAL OF NEUROSURGERY | AMER ASSOC NEUROLOGICAL SURGEONS | Published : 2017
OBJECTIVE MicroRNAs (miRNAs) regulate gene expression and therefore play important roles in many physiological and pathological processes. The aim of this pilot study was to determine the feasibility of extraction and subsequent profiling of miRNA from CSF samples in a pilot population of aneurysmal subarachnoid hemorrhage patients and establish if there is a distinct CSF miRNA signature between patients who develop cerebral vasospasm and those who do not. METHODS CSF samples were taken at various time points during the clinical management of a subset of SAH patients (SAH patient samples without vasospasm, n = 10; SAH patient samples with vasospasm, n = 10). CSF obtained from 4 patients with..View full abstract
The study received funding from The Royal Melbourne Hospital Neuroscience Foundation and the John T. Reid Charitable Trusts.