CHANGES IN GANGLION CELLS DURING RETINAL DEGENERATION
Susmita Saha, Ursula Greferath, Kirstan A Vessey, David B Grayden, Anthony N Burkitt, Erica L Fletcher
NEUROSCIENCE | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2016
Inherited retinal degeneration such as retinitis pigmentosa (RP) is associated with photoreceptor loss and concomitant morphological and functional changes in the inner retina. It is not known whether these changes are associated with changes in the density and distribution of synaptic inputs to retinal ganglion cells (RGCs). We quantified changes in ganglion cell density in rd1 and age-matched C57BL/6J-(wildtype, WT) mice using the immunocytochemical marker, RBPMS. Our data revealed that following complete loss of photoreceptors, (∼3months of age), there was a reduction in ganglion cell density in the peripheral retina. We next examined changes in synaptic inputs to A type ganglion cells by..View full abstract
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Awarded by National Health and Medical Research Council (Australia)
This work was supported by the National Health and Medical Research Council (Australia) project grant (APP1021042), by Retina Australia, and the Australian Research Council, through its Special Research Initiative in Bionic Vision Science and Technology grant to Bionic Vision Australia.