Journal article
Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women
KA Bates, HR Sohrabi, SR Rainey-Smith, M Weinborn, RS Bucks, M Rodrigues, J Beilby, M Howard, K Taddei, G Martins, A Paton, T Shah, SS Dhaliwal, JK Foster, IJ Martins, NT Lautenschlager, FL Mastaglia, SE Gandy, RN Martins
International Journal of Neuroscience | TAYLOR & FRANCIS LTD | Published : 2017
Abstract
Purpose/Aim of the study: Poor cardiovascular health, including obesity and altered lipid profiles at mid-life, are linked to increased risk of Alzheimer's disease (AD). The biological mechanisms linking cardiovascular health and cognitive function are unclear though are likely to be multifactorial. This study examined the association between various lipoproteins and cognitive functioning in ageing women. Materials and Methods: We investigated the relationship between readily available biomarkers (i.e. serum lipoprotein) and cognitive decline in domains associated with increased risk of AD (e.g. episodic verbal memory performance and subjective memory complaint). We report cross-sectional da..
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Awarded by National Institute on Aging
Funding Acknowledgements
Ralph N. Martins is the founder, and owns stocks of Alzhyme. Hamid R. Sohrabi has previously received payments from Wyeth and Pfizer, and receives remuneration for ongoing work undertaken as part of the Takeda TOMMORROW Study Clinical Trial. Jonathan K. Foster has previously received payment from Pfizer. Samuel Gandy is a consultant for, owns stock/options in, and/or has received lecture fees from Amicus, Diagenic, Epix, Smart Pharma and Wyeth/Elan. Samuel Gandy is also a member of the data safety monitoring board for the Alzheimer Immunotherapy Alliance and holds a grant from Amicus Pharmaceuticals. There are no other actual or potential conflicts of interest. Kristyn A. Bates is supported by grants funded by the Raine Medical Research Foundation (Western Australia) and the Neurotrauma Research Program (Western Australia). Hamid R. Sohrabi is supported by grants and funds from Edith Cowan University, Cooperative Research Centre for Mental Health-Australia, the Neurotrauma Research Program and the McCusker Charitable Foundation (Western Australia). This study was supported by the National Health and Medical Research Council of Australia (Grant Number: 324100 awarded to Ralph N. Martins), the McCusker Alzheimer's Research Foundation Inc., Hollywood Private Hospital, and the McCusker Charitable Foundation.