Predictors of Long-Term Disability Accrual in Relapse-Onset Multiple Sclerosis
Vilija G Jokubaitis, Tim Spelman, Tomas Kalincik, Johannes Lorscheider, Eva Havrdova, Dana Horakova, Pierre Duquette, Marc Girard, Alexandre Prat, Guillermo Izquierdo, Pierre Grammond, Vincent Van Pesch, Eugenio Pucci, Francois Grand'Maison, Raymond Hupperts, Franco Granella, Patrizia Sola, Roberto Bergamaschi, Gerardo Iuliano, Daniele Spitaleri Show all
ANNALS OF NEUROLOGY | WILEY | Published : 2016
OBJECTIVE: To identify predictors of 10-year Expanded Disability Status Scale (EDSS) change after treatment initiation in patients with relapse-onset multiple sclerosis. METHODS: Using data obtained from MSBase, we defined baseline as the date of first injectable therapy initiation. Patients need only have remained on injectable therapy for 1 day and were monitored on any approved disease-modifying therapy, or no therapy thereafter. Median EDSS score changes over a 10-year period were determined. Predictors of EDSS change were then assessed using median quantile regression analysis. Sensitivity analyses were further performed. RESULTS: We identified 2,466 patients followed up for at least 10..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NHMRC Centre for Research Excellence
This investigator-initiated analysis was supported by a project grant from the National Health and Medical Research Council (NHMRC; 1032484) and an NHMRC Centre for Research Excellence grant (1001216).