Journal article
Axon density and axon orientation dispersion in children born preterm
CE Kelly, DK Thompson, J Chen, A Leemans, CL Adamson, TE Inder, JLY Cheong, LW Doyle, PJ Anderson
Human Brain Mapping | WILEY | Published : 2016
DOI: 10.1002/hbm.23227
Abstract
Background: Very preterm birth (VPT, <32 weeks' gestation) is associated with altered white matter fractional anisotropy (FA), the biological basis of which is uncertain but may relate to changes in axon density and/or dispersion, which can be measured using Neurite Orientation Dispersion and Density Imaging (NODDI). This study aimed to compare whole brain white matter FA, axon dispersion, and axon density between VPT children and controls (born ≥37 weeks' gestation), and to investigate associations with perinatal factors and neurodevelopmental outcomes. Methods: FA, neurite dispersion, and neurite density were estimated from multishell diffusion magnetic resonance images for 145 VPT and 33 ..
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Awarded by National Institute of Child Health and Human Development
Funding Acknowledgements
Contract grant sponsor: National Institutes of Health (NIH); Contract grant numbers: R01 HD05709801, P30 HD062171, and UL1 TR000448 to T.E.I.; Contract grant sponsor: The National Health and Medical Research Council (NHMRC) of Australia; Contract grant number: Project Grant No. 237117 to T.E.I. and L.W.D.; Project Grant No. 491209 to P.J.A., T.E.I. and L.W.D.; Contract grant sponsor: Centre of Research Excellence; Contract grant number: No. 1060733 to L.W.D., P.J.A, J.L.Y.C. and D.K.T.; Contract grant sponsor: Senior Research Fellowship; Contract grant number: No. 1081288 to P.J.A.; Contract grant sponsor: Career Development Fellowship; Contract grant number: No. 1085754 to D.K.T.; Contract grant sponsor: Early Career Fellowship; Contract grant numbers: No. 1012236 to D.K.T. and 1053787 to J.L.Y.C; Contract grant sponsor: the United Cerebral Palsy Foundation, The United States to T.E.I.; Contract grant sponsors: The Victorian Government's Operational Infrastructure Support Program, the Royal Children's Hospital Foundation, and the Netherlands Organisation for Scientific Research (NWO); Contract grant number: VIDI Grant 639.072.411 to A.L.