Oral microbial biofilm models and their application to the testing of anticariogenic agents
Christina PC Sim, Stuart G Dashper, Eric C Reynolds
JOURNAL OF DENTISTRY | ELSEVIER SCI LTD | Published : 2016
OBJECTIVES: This review paper evaluates the use of in vitro biofilm models for the testing of anticariogenic agents. DATA: Caries is a biofilm-mediated oral disease and in vitro biofilm models have been widely utilised to assess how anticariogenic or antimicrobial agents affect the de/remineralisation process of caries. The use of enamel or dentine substrata has enabled the assessment of the relationship between bacterial activity and caries lesion initiation and progression and how this relationship could be affected by the agent under study. SOURCES: Only papers published in the English literature were reviewed. STUDY SELECTION: Both 'open' and 'closed' biofilm systems utilising either sin..View full abstract
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Supported by the Australian Government, Department of Industry, Innovation and Science. Dr CPC Sim is a recipient of a Singaporean National Medical Research Council Research Training Fellowship. We thank Deanne Catmull for the flow cell and biofilm images.